Trpa1 Mouse shRNA Plasmid (Locus ID 277328)
SKU
TL508157
Trpa1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 277328 |
|---|---|
| Synonyms | Anktm1; TRPA1b |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Trpa1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 277328). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC120563, BC131963, NM_177781, NM_001348288, NM_177781.1, NM_177781.2, NM_177781.3, NM_177781.4, NM_177781.5 |
| UniProt ID | Q8BLA8 |
| Summary | Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Is also activated by menthol (in vitro) (By similarity). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception
Hall, Prochazkova, Sapio et al
Sci Rep (2018) 8 (1), 1177 DOI: 10.1038/s41598-018-19532-6
Hall, Prochazkova, Sapio et al
Sci Rep (2018) 8 (1), 1177 DOI: 10.1038/s41598-018-19532-6
AI Summary: OriGene's FLAG-tagged and untagged mouse TRPA1 expression vectors were used to express TRPA1 in cell lines, enabling the study of its phosphorylation by Cdk5 and its role in chemo-nociception.
Snippet: FLAG tagged and untagged mouse TRPA1 expression vectors were purchased from Origene (Rockville, MD). The mouse neuroblastoma cell line Neuro-2a was cultured in DMEM and 10% fetal bovine serum and the cells were transfected with the TRPA1 constructs using Neuro-2a Cell Avalanche Transfection Reagent (EZ Biosystems, College Park, MD)
Showing 1-1 of 1 papers.
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