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Gpr119 Mouse shRNA Plasmid (Locus ID 236781)

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SKU
TL507165
Gpr119 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 236781
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Gpr119 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 236781). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC115557, BC115558, NM_181751, NM_181751.1, NM_181751.2
UniProt ID Q7TQP3
Summary Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol
Yang, Qi, Li et al
Nat Commun (2023) 14 (1), 228 DOI: 10.1038/s41467-023-35861-1
Cited by 120
AI Summary: OriGene's Mouse Gpr119 shRNA lentiviral particles (catalog #TL507165V) and scrambled shRNA lentiviral particles were used in this study to investigate the role of GPR119 signaling in mediating the effects of 2-oleoylglycerol on liver inflammation and fibrosis in non-alcoholic steatohepatitis.
Snippet: Mouse Gpr119 shRNA lentiviral particles and scrambled shRNA lentiviral particles were purchased from OriGene Technologies, Inc., (catalog #TL507165V, Rockville, MD)
FigureFigureFigure
Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists
Fang, Yang, Gundeti et al
Bioorg Med Chem (2017) 25 (1), 254-260 DOI: 10.1016/j.bmc.2016.10.030
Cited by 18
AI Summary: In this study, OriGene’s GPR119 cDNA (Cat# RC212651) was used to express the human GPR119 receptor in functional assays, enabling the evaluation of the synthesized 5-nitropyrimidine derivatives as GPR119 agonists.
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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