Phgdh Mouse shRNA Plasmid (Locus ID 236539)
SKU
TL507159
Phgdh - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 236539 |
|---|---|
| Synonyms | 3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD; PGDH; SERA |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Phgdh - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 236539). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC086668, BC110673, NM_016966, NM_016966.1, NM_016966.2, NM_016966.3, BC027566 |
| UniProt ID | Q61753 |
| Summary | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells
Białopiotrowicz, Noyszewska-Kania, Kachamakova-Trojanowska et al
Cancers (Basel) (2020) 12 (3) DOI: 10.3390/cancers12030580
Białopiotrowicz, Noyszewska-Kania, Kachamakova-Trojanowska et al
Cancers (Basel) (2020) 12 (3) DOI: 10.3390/cancers12030580
Cited by 67
AI Summary: OriGene’s 29-mer shRNA constructs in pGFP-C-shLenti vectors were used to generate PSAT1 and PHGDH knockdown MDA-MB-468 cells, enabling the study of serine biosynthesis pathway disruption in Burkitt lymphoma.
Snippet: MDA-MB-468 cells with PSAT1/PHGDH knockdown were generated using 29-mer shRNA constructs in pGFP-C-shLenti vectors (purchased from OriGene, Rockville, MD, USA), and pMD2.G and psPAX2as as described previously [45]. After 72 h from transduction, the GFP positive cells were sorted using MoFlo XDP cell sorter (Beckman-Coulter)
Showing 1-1 of 1 papers.
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