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Lpcat1 Mouse shRNA Plasmid (Locus ID 210992)

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SKU
TL506307
Lpcat1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 210992
Synonyms 2900035H07Rik; Aytl2; BB137372; BC005662; C87117; LPCAT; rd11
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Lpcat1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 210992). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC066809, NM_145376, NM_145376.1, NM_145376.2, NM_145376.3, NM_145376.4, NM_145376.5, BC005662, NM_001368681, NM_001368682, NM_145376.6
UniProt ID Q3TFD2
Summary Possesses both acyltransferase and acetyltransferase activities (PubMed:16704971). Activity is calcium-independent (PubMed:18285344). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:16704971, PubMed:18156367). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971, PubMed:18285344). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16704971). Involved in the regulation of lipid droplet number and size (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Acyl-CoA:lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis
Zou, Ellis, Smith et al
J. Biol. Chem. (2011) 286 (32), 28019-25 DOI: 10.1074/jbc.M111.253385
Cited by 12
AI Summary: OriGene products, specifically the Lpcat1 small hairpin RNA (shRNA) plasmid and SPTLC2 recombinant proteins, were used in this study to knock down Lpcat1 expression and analyze protein function, enabling the authors to investigate Lpcat1's role in histone H4 O-palmitoylation and its impact on mRNA synthesis.
Snippet: palmitoyltransferase long chain base subunit 2 (SPTLC2) recombinant proteins and Lpcat1 small hairpin RNA (shRNA) plasmid were from Origene (Rockville, MD ... After incubation with 30 μl of protein A/G-agarose beads for another 3 h, beads were spun down and washed with
Showing 1-1 of 1 papers.
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