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Atg7 Mouse shRNA Plasmid (Locus ID 74244)

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SKU
TL504956
Atg7 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "Atg7 or NM_001253717"

Specifications
Specifications
Product Data
Locus ID 74244
Synonyms 1810013K23Rik; Agp7; Apg7l; Atg7l; Gm21553
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Atg7 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 74244). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC058597, NM_001253717, NM_001253718, NM_028835, NM_028835.1, NM_028835.3, NM_028835.4, NM_001253718.1, NM_001253717.1, NM_001253718.2, NM_028835.5, NM_001253717.2
UniProt ID Q9D906
Summary This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Altered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype
Nahapetyan, Moulis, Grousset et al
Cell Death Dis (2019) 10 (2), 119 DOI: 10.1038/s41419-019-1400-0
AI Summary: OriGene's Atg7-targeted shRNA lentiviral particles (TL504956V) were used to specifically knock down Atg7 expression in VSMCs, enabling the study of how impaired autophagy affects mitochondrial quality control and plaque stability.
Snippet: by self-inactivating lentiviral particles at 20 multiplicity of infection, for the expression of plasmids with a gene coding for green fluorescent protein (GFP), a puromycin resistance gene, and an Atg7-targeted or scramble short hairpin RNA (shRNA) gene (Origene, TL504956V
FigureFigureFigure
Showing 1-1 of 1 papers.
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