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Insig2 Mouse shRNA Plasmid (Locus ID 72999)

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SKU
TL504791
Insig2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 72999
Synonyms 2900053I11Rik; C730043J18Rik; Insig-2
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Insig2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 72999). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC015288, BC023067, BC023874, BC024411, NM_001271531, NM_001271532, NM_133748, NM_178082, NM_001357251, NM_178082.1, NM_178082.2, NM_178082.3, NM_133748.1, NM_133748.2, NM_001271532.1, NM_001271531.1
UniProt ID Q91WG1
Summary Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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