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Amer1 Mouse shRNA Plasmid (Locus ID 72345)

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SKU
TL504729
Amer1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "Amer1 or NM_175179"

Specifications
Specifications
Product Data
Locus ID 72345
Synonyms 2810002O09Rik; AW492303; Fam123b; Wtx
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Amer1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 72345). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_175179, NM_175179.1, NM_175179.2, NM_175179.3, NM_175179.4, BC053442, BC060714, BC096616
UniProt ID Q7TS75
Summary Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
Palumbo, De Luca, Rosato et al
J Transl Med (2016) 14 (1), 37 DOI: 10.1186/s12967-016-0796-x
Cited by 29
AI Summary: OriGene’s JNK1 shRNA vectors were used in this study to silence JNK1 expression, enabling the authors to demonstrate that JNK activity is required for nitrobenzoxadiazole-induced inhibition of autophagic flux in tumor cells.
Snippet: The autophagic flux index of NBD-treated cultures was expressed in proportion to that of untreated cultures, which was arbitrarily set equal to 1. JNK1 RNA interference. Vectors for JNK1 RNA interference were purchased from OriGene Technologies, Rockville, MD, ... Cite SaveSaving
FigureFigureFigure
Showing 1-1 of 1 papers.
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