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Ngb Mouse shRNA Plasmid (Locus ID 64242)

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SKU
TL503454
Ngb - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 64242
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ngb - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 64242). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC024263, NM_001294308, NM_022414, NM_022414.1, NM_022414.2, NM_001294308.1
UniProt ID Q9ER97
Summary Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology
de Vidania, Palomares-Perez, Frank-García et al
Front Neurosci (2020) 14, 562581 DOI: 10.3389/fnins.2020.562581
Cited by 22
AI Summary: OriGene products contributed to this study by providing the Ngb silencing plasmid (sh-Ngb, TL503454a), the scrambled control plasmid (Scr, TR30021), and the Ngb overexpression plasmid (NM_021257), which were used to manipulate Neuroglobin expression in experiments investigating its protective role against Alzheimer's pathology.
Snippet: for the Ngb silencing experiment, a silencing plasmid (sh-Ngb) (Origene, TL503454a) or a scrambled (Scr) (Origene, TR30021) were used, while for the Ngb overexpression experiment, a plasmid containing the sequence for Ngb expression (Origene, NM_021257) was used
FigureFigureFigure
Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons
Yu, Liu, Li et al
Neurobiol. Dis. (2013) 56, 95-103 DOI: 10.1016/j.nbd.2013.04.015
Cited by 80
AI Summary: OriGene’s neuroglobin (Ngb) overexpression plasmid was used to transfect primary cultured mouse cortical neurons, enabling the study to demonstrate that Ngb overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening.
Snippet: Co-immunoprecipitation (Co-IP) was performed using Immunoprecipitation Kit-Dynabeads Protein A (Life Technologies, Grand Island, NY ... V-RS, and the plasmid was transfected into primary cultured neurons following the manufacturer's instruction (OriGene, Rockville, MD).
Estudio de los mecanismos neuroprotectores frente a la toxicidad del péptido#-amiloide en un modelo preclínico de la enfermedad de Alzheimer
Vidania Ballesteros
Thesis (2019)
Snippet: … Programa de Doctorado en Biociencias Moleculares Estudio de los mecanismos neuroprotectores frente a la toxicidad del peptido β-amiloide en un modelo preclinico de la enfermedad de Alzheimer Silvia de Vidania Ballesteros Madrid, 2019 Page 2 View as HTML;(Origene: TR30021): contiene un casete de silenciamiento no efectivo con una secuencia aleatoria de nucleótidos (ver Figura 3.4) Plásmido de silenciamiento (sh-NGB) (Origene, TL503454): contiene una horquilla de shRNA con una secuencia de silenciamiento de 29 pb (siRNA) que presenta un 100% de alineamiento con el ARNm de ratón (ver Figura 3.4)
Showing 1-3 of 3 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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