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Crbn Mouse shRNA Plasmid (Locus ID 58799)

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SKU
TL503372
Crbn - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 58799
Synonyms 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; piL
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Crbn - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 58799). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC086488, NM_021449, NM_175357, NM_175357.1, NM_175357.2, NM_175357.3, NM_021449.1, NM_021449.2, NM_021449.3, BC033458, BC046967, BC069905
UniProt ID Q8C7D2
Summary This gene encodes a protein with a Lon protease domain, a "regulators of G protein-signaling" (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic cognitive disability. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. provided by RefSeq, Jan 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
Shen, Nayak, Neitzel et al
Nat Commun (2021) 12 (1), 5263 DOI: 10.1038/s41467-021-25634-z
Cited by 44
AI Summary: OriGene products, specifically lentiviral shRNA constructs targeting human CRBN (TL305228V #B, TL205228V #D), mouse Crbn (TL503372V #A-D), and a mouse Scramble control (TR30021V), were used in this study to manipulate CRBN expression and investigate its role in Wnt signaling.
Snippet: 021086-11-0005). Lentiviral expressing shRNA targeting human CRBN (#1: TL305228V #B;#2: TL205228V #D), mouse Scramble control (TR30021V), or mouse Crbn (#A-D: TL503372V #A, B, C, D) were purchased (Origene). Cell-based assays HEK293T (HEK), HEK293STF, NIH3T3, and L-WRN cells were purchased from American Type Culture Collection (ATCC) and maintained as recommended. Cells (50–70% confluent) wer
FigureFigureFigure
Showing 1-1 of 1 papers.
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