Impdh2 Mouse shRNA Plasmid (Locus ID 23918)
SKU
TL502514
Impdh2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 23918 |
|---|---|
| Synonyms | IMPD |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Impdh2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 23918). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC010314, BC052671, NM_011830, NM_011830.1, NM_011830.2, NM_011830.3 |
| UniProt ID | P24547 |
| Summary | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells
Fellenberg, Kunz, Sähr et al
PLoS One (2010) 5 (8), e12179 DOI: 10.1371/journal.pone.0012179
Fellenberg, Kunz, Sähr et al
PLoS One (2010) 5 (8), e12179 DOI: 10.1371/journal.pone.0012179
Cited by 43
AI Summary: OriGene products, specifically the IMPDH2 cDNA clone and IMPDH2 shRNA lentiviral particles, were used to generate osteosarcoma cell lines with IMPDH2 overexpression and knockdown, enabling the study of IMPDH2's role in chemoresistance.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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