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Vrk1 Mouse shRNA Plasmid (Locus ID 22367)

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SKU
TL502417
Vrk1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 22367
Synonyms 51PK
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Vrk1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 22367). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC016676, BC051072, NM_001029843, NM_001029844, NM_011705, NM_001029844.1, NM_011705.1, NM_011705.2, NM_011705.3, NM_001029843.1, NM_001364365, NM_001364367, NM_001364368, NM_001029843.2, NM_011705.4
UniProt ID Q80X41
Summary Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
Moura, Fernández, Marín-Royo et al
Sci Rep (2016) 6, 28532 DOI: 10.1038/srep28532
Cited by 23
AI Summary: OriGene’s pCMV6-myc-Flag-Sox2 plasmid was used in this study to express Sox2 and investigate its regulatory role and cooperation with VRK1 in cell cycle progression and differentiation.
Snippet: Human CCND1 gene promoter was studied with pA3-CyclinD1-Luc (wt −1745 + 134)59. Plasmids expressing macroH2A1.1 macroH2A1.2 and macroH2A2 were from M. Buschbeck43. Sox2: pCMV6-myc-Flag-Sox2 (Origene;Rockville, MD) or pBabe-Sox2. Sox4: pCDNA3.1-Sox4, pCDNA3.1-Sox4(S395X), and pCDNA3.1-Sox4(A350P)60
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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