Ube3a Mouse shRNA Plasmid (Locus ID 22215)
SKU
TL502369
Ube3a - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 22215 |
|---|---|
| Synonyms | 4732496B02; 5830462N02Rik; A130086L21Rik; Hpve6a; mKIAA4216 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Ube3a - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 22215). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC131658, BC131659, NM_001033962, NM_011668, NM_173010, NM_173010.1, NM_173010.2, NM_173010.3, NM_011668.1, NM_011668.2, NM_001033962.1, BC094605, NM_001033962.2, NM_011668.3 |
| UniProt ID | O08759 |
| Summary | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:20211139, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (PubMed:20211139). Synergizes with WBP2 in enhancing PGR activity (By similarity).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Impairment of TrkB-PSD-95 signaling in Angelman syndrome
Cao, Rioult-Pedotti, Migani et al
PLoS Biol. (2013) 11 (2), e1001478 DOI: 10.1371/journal.pbio.1001478
Cao, Rioult-Pedotti, Migani et al
PLoS Biol. (2013) 11 (2), e1001478 DOI: 10.1371/journal.pbio.1001478
Cited by 179
AI Summary: OriGene products, specifically the Arc/Arg3.1 (mouse) antibody (Cat# TA336282) and Ube3A (mouse) antibody (Cat# TA324234), were used in this study to detect and analyze protein expression levels, helping to elucidate the role of Arc and Ube3A in impaired TrkB-PSD-95 signaling in Angelman syndrome.
Showing 1-1 of 1 papers.
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in shipping.
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