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Top2a Mouse shRNA Plasmid (Locus ID 21973)

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SKU
TL502310
Top2a - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "Top2a or NM_011623"

Specifications
Specifications
Product Data
Locus ID 21973
Synonyms Top-2
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Top2a - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 21973). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_011623, NM_011623.1, NM_011623.2, BC008170, BC057873, BC094326
UniProt ID Q01320
Summary Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (PubMed:24321095).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

TOP2A Promotes Cell Migration, Invasion and Epithelial-Mesenchymal Transition in Cervical Cancer via Activating the PI3K/AKT Signaling
Wang, Shen, Zou et al
Cancer Manag Res (2020) 12, 3807-3814 DOI: 10.2147/CMAR.S240577
AI Summary: OriGene products, specifically the TOP2A overexpression plasmid (RC209663) and TOP2A siRNA (SR321093), were used in this study to manipulate TOP2A levels in cervical cancer cells, enabling the authors to investigate the role of TOP2A in cell migration, invasion, and EMT.
FigureFigureFigure
Showing 1-1 of 1 papers.
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