Ccl2 Mouse shRNA Plasmid (Locus ID 20296)
SKU
TL501987
Ccl2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 20296 |
|---|---|
| Synonyms | AI323594; HC11; JE; MCA; MCAF; MCP; MCP-; MCP-1; MCP1; Scy; Scya2; Sig; Sigje; SMC-C; SMC-CF |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Ccl2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 20296). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_011333, NM_011333.1, NM_011333.2, NM_011333.3, BC145867, BC055070, BC145869 |
| UniProt ID | P10148 |
| Summary | This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. provided by RefSeq, Sep 2015 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Improved insulin sensitivity in obese-diabetic mice via chitosan Nanomicelles mediated silencing of pro-inflammatory Adipocytokines
Sharma, Arora, Banerjee et al
Nanomedicine (2021) 33, 102357 DOI: 10.1016/j.nano.2020.102357
Sharma, Arora, Banerjee et al
Nanomedicine (2021) 33, 102357 DOI: 10.1016/j.nano.2020.102357
Cited by 25
AI Summary: OriGene contributed to this study by providing plasmids encoding shRNA targeting TNFα and MCP-1 (from OriGene Technologies Inc.), which were used to silence pro-inflammatory adipocytokines and improve insulin sensitivity in obese-diabetic mice.
Snippet: Skip to article;Four unique plasmids encoding shRNA directed towardeach adipocytokine (TNFαor MCP-1) were acquired fromOrigene (Origene Technologies Inc., Rockville, MD, USA)and the constructs showing maximum downregulation wereused for all further analyses
Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke
Mao, Li, Zhu et al
Brain (2017)
Mao, Li, Zhu et al
Brain (2017)
Cited by 180
AI Summary: OriGene products contributed to this study by providing lentiviral vectors expressing shRNA against murine Ccl2 and a scrambled control sequence, which were used to knock down Ccl2 in endothelial cells and investigate the role of CCL2 in regulatory T cell-mediated protection of the blood-brain barrier after stroke.
Showing 1-2 of 2 papers.
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