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Rlim Mouse shRNA Plasmid (Locus ID 19820)

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SKU
TL501910
Rlim - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 19820
Synonyms AL022832; AW743871; Ha1r; Rlim1; Rnf12
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Rlim - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 19820). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC012960, NM_011276, NM_001358205, NM_011276.1, NM_011276.2, NM_011276.3, BC053711, NM_011276.4
UniProt ID Q9WTV7
Summary E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression
Li, Yang, Wang et al
J Mol Cell Biol (2022) 14 (1) DOI: 10.1093/jmcb/mjab082
Cited by 14
AI Summary: In this study, OriGene products—including the RLIM (Myc-DDK-tagged) expression plasmid (RC221834) and RLIM shRNA plasmid (TL309560)—were used to manipulate RLIM expression levels, enabling the authors to investigate RLIM’s role in stabilizing ZC4H2 and RNF220 during cerebellum development and Shh-group medulloblastoma progression.
Snippet: needed to study its potential role during cerebellum development. RLIM has been reported to be involved in cancer development with diverse functions through targeting different proteins. In lung tumorigenesis, RLIM is involved in p53 regulation through the TRIM28‒RLIM‒MDM2 axis and restrains cell proliferation by targeting c-myc (Gao et al., 2016;Jin et al., 2020). It was also reported that
FigureFigureFigure
Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer
Johnsen, Güngör, Prenzel et al
Cancer Res (2009) 69 (1), 128-36 DOI: 10.1158/0008-5472.CAN-08-1630
AI Summary: In this study, OriGene products—including the CLIM (FHL2) and RLIM (RNF12) expression plasmids—were used to investigate the roles of these LIM cofactors in regulating estrogen receptor alpha (ERα) transcriptional activity in breast cancer cells.
FigureFigure
Showing 1-2 of 2 papers.
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