Prkab1 Mouse shRNA Plasmid (Locus ID 19079)
SKU
TL501734
Prkab1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 19079 |
|---|---|
| Synonyms | 1300015D22Rik; AU021155; E430008F22 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Prkab1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 19079). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC016398, NM_031869, NM_031869.1, NM_031869.2, BC027650 |
| UniProt ID | Q9R078 |
| Summary | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
AMP kinase promotes glioblastoma bioenergetics and tumour growth
Chhipa, Fan, Anderson et al
Nat. Cell Biol. (2018)
Chhipa, Fan, Anderson et al
Nat. Cell Biol. (2018)
AI Summary: OriGene’s AMPKβ2 shRNA clone was used in this study to specifically knock down AMPKβ2 expression, enabling the authors to investigate the role of this AMPK subunit in glioblastoma stem cell bioenergetics and tumor growth.
Snippet: Article.;Several independent shRNA sequences were screened for each of the used human target genes, and the sequences which exhibited maximal knockdown were used for the study. Most shRNA clones (in pLKO.1 plasmid) were from the Sigma Mission RNAi shRNA library. The AMPKβ2 shRNA clone was purchased from OriGene
Showing 1-1 of 1 papers.
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