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Per1 Mouse shRNA Plasmid (Locus ID 18626)

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SKU
TL501619
Per1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "Per1 or NM_001159367"

Specifications
Specifications
Product Data
Locus ID 18626
Synonyms Hftm; m-rigui; mPer1; Per
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Per1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 18626). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC039768, BC091645, NM_001159367, NM_011065, NM_011065.1, NM_011065.2, NM_011065.3, NM_011065.4, NM_001159367.1, NM_001159367.2, NM_011065.5
UniProt ID O35973
Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Jan 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Light affects behavioral despair involving the clock gene Period 1
Olejniczak, Ripperger, Sandrelli et al
PLoS Genet (2021) 17 (7), e1009625 DOI: 10.1371/journal.pgen.1009625
Cited by 39
AI Summary: In this study, OriGene products—specifically the Per1 knockout mouse model and Per1-specific shRNA—were used to investigate the role of the clock gene Period1 (Per1) in mediating the effects of light on mood-related behaviors in mice.
FigureFigureFigure
Light affects behavioral despair involving the clock gene Period 1
Olejniczak, Ripperger, Sandrelli et al
bioRxiv (2020)
Cited by 1
Snippet: Recombinant DNA reagent Per1 Mouse shRNA Plasmid (Locus ID 18626) Origene CAT#: TL501619 Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector
Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK
Rawashdeh, Jilg, Maronde et al
J. Neurochem. (2016)
Cited by 77
AI Summary: In this study, OriGene's Per1-directed short hairpin RNAs (sh-Per1) were used to knock down endogenous PER1 in hippocampal cells, enabling the authors to investigate PER1's role in regulating circadian modulation of memory-relevant signaling.
Snippet: reporter plasmid (Promega, USA), and either an equal mix of four Per1-directed short hairpin RNAs (sh-Per1) (OriGene Technologies, Inc., USA), or scrambled RNA, using the FuGene HD kit (Promega, Mannheim, Germany). Cells ... Related articles All 3 versions Cite SaveSaving
Showing 1-3 of 3 papers.
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