Mapt Mouse shRNA Plasmid (Locus ID 17762)

SKU TL501388

Mapt - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 17762
• Synonyms: AI413597; AW045860; Mtapt; Tau
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: Mapt - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 17762). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: BC014748, NM_001038609, NM_001285454, NM_001285455, NM_001285456, NM_010838, NM_010838.1, NM_010838.2, NM_010838.3, NM_010838.4, NM_001038609.1, NM_001038609.2, NM_001285456.1, NM_001285455.1, NM_001285454.1, BM950831
• UniProt ID: P10637
• Summary: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.[UniProtKB/Swiss-Prot Function]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient