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Hap1 Mouse shRNA Plasmid (Locus ID 15114)

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SKU
TL500930
Hap1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "Hap1 or NM_010404"

Specifications
Specifications
Product Data
Locus ID 15114
Synonyms HAP; HAP-1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Hap1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 15114). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC034089, BC053043, NM_010404, NM_177981, NM_177981.1, NM_177981.2, NM_010404.1, NM_010404.2, NM_010404.3
UniProt ID O35668
Summary The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein huntingtin. The protein also interacts with kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Apr 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington's Disease
Czeredys, Vigont, Boeva et al
Front Cell Neurosci (2018) 12, 381 DOI: 10.3389/fncel.2018.00381
AI Summary: OriGene products contributed to this study by providing HAP1A and HAP1B mouse cDNA clones in pCMV6-ENTRY (catalog no. NM010404, NM177981), pLenti-C-mGFP vector (catalog no. PS100071) for HAP1 overexpression, shRNA sequences in pLenti-GFP (catalog no. TL500930C) for HAP1 silencing, and scrambled shRNA controls (catalog no. TR30021), enabling the researchers to manipulate HAP1 expression and assess its role in calcium signaling in Huntington’s disease models.
Snippet: HAP1A or HAP1B mouse cDNA clones in pCMV6-ENTRY that originated from Origene (catalog no. NM010404 or NM177981) were cloned between the SgfI and MluI sites into pLenti-C-mGFP (catalog no. PS100071, Origene) for HAP1 overexpression. For HAP1 silencing, commercially available short-hairpin RNA (shRNA) sequences in pLenti-GFP (catalog no. TL500930C, Origene) were used. … TR30021, Origene)
FigureFigureFigure
Showing 1-1 of 1 papers.
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