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Glra1 Mouse shRNA Plasmid (Locus ID 14654)

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SKU
TL500822
Glra1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "Glra1 or NM_001290821"

Specifications
Specifications
Product Data
Locus ID 14654
Synonyms nmf11; oscillator; ot; spasmodic; spd
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Glra1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 14654). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC131949, NM_001290821, NM_020492, NM_020492.1, NM_020492.2, NM_020492.3, NM_020492.4, NM_001290821.1, BC137725
UniProt ID Q64018
Summary Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:16672662, PubMed:17114051, PubMed:24801766). Channel opening is also triggered by taurine and beta-alanine (By similarity). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability (PubMed:9145798). Contributes to the generation of inhibitory postsynaptic currents (PubMed:16672662, PubMed:17114051, PubMed:24801766). Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (PubMed:24801766).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Adeno-Associated Virus-RNAi of GlyRα1 and Characterization of Its Synapse-specific Inhibition in OFF alpha Transient Retinal Ganglion Cells
Zhang, Rompani, Roska et al
J. Neurophysiol. (2014)
Cited by 7
AI Summary: OriGene’s pCMV6-AC-GFP plasmid, containing the mouse Glra1 cDNA open reading frame, was used to express GlyRα1 in HEK293T cells to assess the efficiency of Glra1-targeting and scrambled shRNA constructs in this study.
Snippet: The 117 efficiency of each of three Glra1 and a scrambled shRNA construct were assessed in cultured 118 HEK293T cells after co-transfection with a plasmid expressing GlyRα1 (pCMV6-AC-GFP, 119 carrying mouse Glra1 cDNA open reading frame (OriGene)). 120 ... Cite SaveSaving
Showing 1-1 of 1 papers.
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