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Gata4 Mouse shRNA Plasmid (Locus ID 14463)

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SKU
TL500773
Gata4 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 14463
Synonyms Gata-4
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Gata4 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 14463). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001310610, NM_008092, NM_008092.1, NM_008092.2, NM_008092.3, NM_008092.4, BC137824
UniProt ID Q08369
Summary Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Meox1 accelerates myocardial hypertrophic decompensation through Gata4
Lu, Wang, Li et al
Cardiovasc. Res. (2017)
Cited by 47
AI Summary: OriGene’s Gata4 shRNAs (pGFP-C-shLenti vector) were used to knock down Gata4 expression in HL-1 cells, enabling the authors to investigate the role of Gata4 in Meox1-mediated myocardial hypertrophic decompensation.
Snippet: in Supplementary material online, Table S1). Gata4 knockdown Four Gata4 shRNAs (Gata4-shRNAs) in a pGFP-C-shLenti vector under the U6 promoter were purchased from ORIGENE, and HL-1 cells were transfected according to the manufacturer's protocol
Evolutionary conservation of glucose-dependent insulinotropic polypeptide (GIP) gene regulation and the enteroinsular axis
Musson, Jepeal, Sharifnia et al
Regul Pept (2010) 164 (2-3), 97-104 DOI: 10.1016/j.regpep.2010.05.007
Cited by 6
AI Summary: In this study, OriGene products—specifically, the PAX4 cDNA clone and PAX4 shRNA—were used for overexpression and gene knockdown experiments to investigate the regulatory role of PAX4 in Danio rerio GIP gene expression.
FigureFigure
GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage
Jepeal, Boylan, Michael Wolfe
Mol Cell Endocrinol (2008) 287 (1-2), 20-9 DOI: 10.1016/j.mce.2008.01.024
Cited by 24
AI Summary: In this study, OriGene products—including GIP cDNA (OriGene, MC204727) and GATA-4 shRNA (OriGene, TG313392)—were used to manipulate gene expression in cell lines, enabling the authors to investigate the regulatory role of GATA-4 in glucose-dependent insulinotropic polypeptide (GIP) expression.
FigureFigure
Showing 1-3 of 3 papers.
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