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Fzd4 Mouse shRNA Plasmid (Locus ID 14366)

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SKU
TL500740
Fzd4 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 14366
Synonyms Fz4
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Fzd4 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 14366). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC015256, NM_008055, NM_008055.1, NM_008055.2, NM_008055.3, NM_008055.4
UniProt ID Q61088
Summary Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Wnt5a/FZD4 Mediates the Mechanical Stretch-Induced Osteogenic Differentiation of Bone Mesenchymal Stem Cells
Gu, Tian, Zhang et al
Cell. Physiol. Biochem. (2018) 48 (1), 215-226 DOI: 10.1159/000491721
AI Summary: OriGene products contributed to this study by providing the pLenti-C-Myc-FZD4 shRNA vectors and empty control vectors (scram-shRNA), which were used to knock down FZD4 expression and investigate its role in mechanical stretch-induced osteogenic differentiation of bone mesenchymal stem cells.
Snippet: The attached BMSCs were used for experiments at passages 3 to 7. The pLenti-C-Myc-FZD4 shRNA vectors that targeted FZD4 and the empty control vectors (scram-shRNA) were purchased from OriGene Technologies, Inc
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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