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Cdh3 Mouse shRNA Plasmid (Locus ID 12560)

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SKU
TL500332
Cdh3 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "Cdh3 or NM_001037809"

Specifications
Specifications
Product Data
Locus ID 12560
Synonyms AI385538; Ca; Cadp; Cdhp; P-cad; P-cadherin; Pc; Pcad
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Cdh3 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 12560). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC098459, NM_001037809, NM_007665, NM_007665.1, NM_007665.2, NM_007665.3, NM_001037809.1, NM_001037809.2, NM_001037809.3, NM_001037809.4, NM_001037809.5, BC052189
UniProt ID P10287
Summary This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. provided by RefSeq, Mar 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration
Hwang, Mathur, Cao et al
Dev Cell (2023) 58 (1), 34-50.e9 DOI: 10.1016/j.devcel.2022.12.005
Cited by 32
AI Summary: OriGene's human (TR30023) and mouse (TL500332) Cdh3 shRNA lentiviral particles were used to deplete Cdh3 expression, enabling the study of its role in leader cell polarization and collective migration in breast tumor models.
Snippet: uid flow groups. shRNA lentiviral depletion of gene expression For each gene targeted (mouse and human), we synthesized 5 different shRNA lentivirus particles – both human and mouse specific Cdh3 (Origene, TR30023 (human), TL500332 (mouse)) and Laminin α3 (Sigma-Aldrich), as well as corresponding scramble (shSCR) controls. shRNA sequences used are listed in key resources table and Table S2. Ea
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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