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Calr Mouse shRNA Plasmid (Locus ID 12317)

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SKU
TL500254
Calr - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 12317
Synonyms Calregulin; CRT
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Calr - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 12317). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC003453, NM_007591, NM_007591.1, NM_007591.2, NM_007591.3
UniProt ID P14211
Summary Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content
Mahdessian, Taxiarchis, Popov et al
Proc Natl Acad Sci U S A (2014) 111 (24), 8913-8 DOI: 10.1073/pnas.1323785111
Cited by 369
AI Summary: In this study, OriGene’s TM6SF2 cDNA clone (RC206307) was used to overexpress TM6SF2 in human liver cells, enabling the researchers to investigate its role in regulating triglyceride secretion and hepatic lipid droplet content.
Showing 1-1 of 1 papers.
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