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Axin1 Mouse shRNA Plasmid (Locus ID 12005)

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SKU
TL500179
Axin1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "Axin1 or NM_001159598"

Specifications
Specifications
Product Data
Locus ID 12005
Synonyms AI316800; Axin; Fu; fused; Kb; Ki; kinky; knobbly
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Axin1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 12005). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC113171, NM_001159598, NM_009733, NM_009733.1, NM_009733.2, NM_001159598.1, BC011544, BC055491, BC069954
UniProt ID O35625
Summary Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Role of zinc transporter ZIP12 in susceptibility-weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function
Strong, Hart, Tang et al
FASEB J. (2020)
AI Summary: OriGene’s 6.6 kb shRNA plasmid was used as the backbone for constructing a minimal mouse ZIP12 shRNA plasmid, enabling targeted ZIP12 gene knockdown to investigate its effects on brain MRI phenotypes and mitochondrial function.
Snippet: A minimal mouse ZIP12 shRNA plasmid (and corresponding control plasmid) was created by ligating the U6 promoter and shRNA cassette of the 6.6 kb shRNA plasmid (Origene, Rockville, MD) RFP replaced with mCherry17 to the origin of replication (ori) and ampicillin
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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