Atm Mouse shRNA Plasmid (Locus ID 11920)
SKU
TL500154
Atm - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 11920 |
|---|---|
| Synonyms | AI256621; C030026E19Rik |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Atm - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 11920). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_007499, NM_007499.1, NM_007499.2, BC067212, BC138525 |
| UniProt ID | Q62388 |
| Summary | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence ST-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment
Chen, Chen, Vail et al
Mol Neurodegener (2016) 11 (1), 60 DOI: 10.1186/s13024-016-0127-y
Chen, Chen, Vail et al
Mol Neurodegener (2016) 11 (1), 60 DOI: 10.1186/s13024-016-0127-y
Cited by 39
AI Summary: In this study, OriGene products—including ATM knockout (KO) mouse models and Atm(-/-) neuronal cells—were used to investigate the effects of glutamine supplementation on neurophysiological function, metabolic parameters, and lifespan in ataxia-telangiectasia models.
Showing 1-1 of 1 papers.
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