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CCR2 Human shRNA Plasmid Kit (Locus ID 729230)

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SKU
TL321181
CCR2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 729230
Synonyms CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components CCR2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 729230). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001123041, NM_001123396, NM_001123396.1, NM_001123041.1, NM_001123041.2, BC126452, BC074751, BC095540, BC136396, NM_001123396.4
UniProt ID P41597
Summary The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. provided by RefSeq, Aug 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

CCL2/CCR2 chemokine signaling modulates ductal breast cancer progression by enhancing glycolysis and c-MET activation
Acevedo
Thesis (2021)
Snippet: control. CCR2 and non-silencing control shRNAs in pGFP-c-shlenti lentivirus vectors were purchased from Origene (cat no. TL321181) CCL2 and non-silencing control Page 53. 32 shRNAs in pGFP-c-shlenti lentivirus vectors were obtained from OriGene (cat no. TL316716
Chemokine Signaling Facilitates Early-stage Breast Cancer Survival and Invasion through Fibroblast-dependent Mechanisms
Brummer, Acevedo, Hu et al
Mol. Cancer Res. (2017)
AI Summary: OriGene products, specifically CCR2 shRNA lentiviral vectors (cat no. TL321181) and CCL2 shRNA lentiviral vectors (cat no. TL316716), were used to selectively silence CCR2 and CCL2 expression, enabling the study of their roles in breast cancer cell survival and invasion.
Snippet: CCR2 and non-silencing control shRNAs in pGFP-c- 107 shlenti lentivirus vectors were purchased from Origene (cat no. TL321181) CCL2 and non-silencing control 109 shRNAs in pGFP-c-shlenti lentivirus vectors were obtained from Origene (cat no. TL316716)
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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