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TLK1 Human shRNA Plasmid Kit (Locus ID 9874)

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SKU
TL320623
TLK1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "TLK1 or NM_001136554"

Specifications
Specifications
Product Data
Locus ID 9874
Synonyms PKU-beta
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components TLK1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 9874). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001136554, NM_001136555, NM_012290, NM_012290.1, NM_012290.2, NM_012290.3, NM_012290.4, NM_001136554.1, NM_001136555.1, BC032657, BC032657.1, NM_001136554.2, NM_001136555.2
UniProt ID Q9UKI8
Summary The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Nov 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

The TLK1-MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells
Khalil, De Benedetti
Cancers (Basel) (2022) 14 (23) DOI: 10.3390/cancers14235728
Cited by 10
AI Summary: OriGene contributed TLK1 shRNA (cat# TL320623), MK5 shRNA (cat# TL320583), and scrambled shRNA (cat# TR30021) constructs, which were used to genetically deplete TLK1 and MK5 and assess their roles in prostate cancer cell motility, invasion, and metastasis.
Snippet: the prevention of PCa cell metastasis in vivo. 2. Materials and Methods 2.1. Plasmids and Antibodies Scrambled, TLK1-, and MK5-specific shRNA constructs in lentiviral GFP vector were purchased from Origene (Rockville, MD, USA, TLK1 shRNA cat# TL320623, MK5 shRNA cat# TL320583, scrambled shRNA cat# TR30021). The following primary antibodies were used in this study: rabbit anti-TLK1 (ThermoFisher,
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Showing 1-1 of 1 papers.
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