MLH1 Human shRNA Plasmid Kit (Locus ID 4292)

SKU TL320419

MLH1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 4292
• Synonyms: COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: MLH1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4292). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_000249, NM_001167617, NM_001167618, NM_001167619, NM_001258271, NM_001258273, NM_001258274, NM_001354615, NM_001354616, NM_001354617, NM_001354618, NM_001354619, NM_001354620, NM_001354621, NM_001354622, NM_001354623, NM_001354624, NM_001354625, NM_001354626, NM_001354627, NM_001354628, NM_001354629, NM_001354630, NM_000249.1, NM_000249.2, NM_000249.3, NM_001167618.1, NM_001167619.1, NM_001167617.1, NM_001258273.1, NM_001258274.1, NM_001258271.1, BC006850, BC006850.1, NM_000249.4, NM_001258274.2, NM_001167617.2
• UniProt ID: P40692
• Summary: The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient