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MLH1 Human shRNA Plasmid Kit (Locus ID 4292)

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SKU
TL320419
MLH1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "MLH1 or NM_000249"

Specifications
Specifications
Product Data
Locus ID 4292
Synonyms COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components MLH1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4292). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_000249, NM_001167617, NM_001167618, NM_001167619, NM_001258271, NM_001258273, NM_001258274, NM_001354615, NM_001354616, NM_001354617, NM_001354618, NM_001354619, NM_001354620, NM_001354621, NM_001354622, NM_001354623, NM_001354624, NM_001354625, NM_001354626, NM_001354627, NM_001354628, NM_001354629, NM_001354630, NM_000249.1, NM_000249.2, NM_000249.3, NM_001167618.1, NM_001167619.1, NM_001167617.1, NM_001258273.1, NM_001258274.1, NM_001258271.1, BC006850, BC006850.1, NM_000249.4, NM_001258274.2, NM_001167617.2
UniProt ID P40692
Summary The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). provided by RefSeq, Aug 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

MicroRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homolog 1
Zhai, Li, Xu et al
Biosci. Rep. (2016)
AI Summary: OriGene products, specifically the pLenti-C-Myc-DDK MLH1 cDNA (RC201607L1) and the MLH1 shRNA plasmid (TL320419), were used in this study to manipulate MLH1 expression and investigate its role as a target of miR-148b in regulating radioresistance in lung cancer cells.
Snippet: pLenti-C-Myc-DDK MLH1 cDNA (RC201607L1) and shRNA plasmid (TL320419) targeting MLH1 were obtained from Origene (Beijing, China). cDNA transfections were performed with Lipofectamine LTX reagent (Invitrogen) as per manufacturer's protocol. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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