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JAK1 Human shRNA Plasmid Kit (Locus ID 3716)

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SKU
TL320394
JAK1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "JAK1 or NM_001320923"

Specifications
Specifications
Product Data
Locus ID 3716
Synonyms AIIDE; JAK1A; JAK1B; JTK3
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components JAK1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3716). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001320923, NM_001321852, NM_001321853, NM_001321854, NM_001321855, NM_001321856, NM_001321857, NM_002227, NM_002227.1, NM_002227.2, NM_002227.3, BC132729, BC009079, BC023604, BC062431, BC111401, NM_002227.4
UniProt ID P23458
Summary This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

IGHG1 functions as an oncogene in tongue squamous cell carcinoma via JAK1/STAT5 signaling
Zheng, Li, Xie et al
Eur Rev Med Pharmacol Sci (2020) 24 (12), 6716-6725 DOI: 10.26355/eurrev_202006_21659
Cited by 1
AI Summary: OriGene products contributed to this study by providing the IGHG1 overexpression plasmid (Cat# RC221491) and IGHG1-specific shRNA lentiviral particles (Cat# TL314531), which were used to manipulate IGHG1 expression in TSCC cell lines and investigate its oncogenic role via JAK1/STAT5 signaling.
IGHG1 functions as an oncogene in tongue squamous cell carcinoma via JAK1/STAT5 signaling
Zheng, Li, Xie et al
Eur Rev Med Pharmacol Sci (2020) 24 (12), 2716-2725 DOI: 10.26355/eurrev_202006_21659
Cited by 1
AI Summary: OriGene contributed to this study by providing the shRNAs used to silence JAK1 and the negative control vector (No. TL320394), which were essential for investigating the role of JAK1 in IGHG1-mediated oncogenic effects in tongue squamous cell carcinoma.
Snippet: … The shRNAs used to silence JAK1 and the sh-NC vector (No. TL320394) were obtained from OriGene (Beijing, China). … The shRNAs used to silence JAK1 and the sh-NC vector (No. TL320394) were obtained from OriGene (Beijing, China). …
Showing 1-2 of 2 papers.
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