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Her2 (ERBB2) Human shRNA Plasmid Kit (Locus ID 2064)

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SKU
TL320342
ERBB2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "Her2 or NM_001005862"

Specifications
Specifications
Product Data
Locus ID 2064
Synonyms CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components ERBB2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 2064). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001005862, NM_001289936, NM_001289937, NM_001289938, NM_004448, NR_110535, NM_004448.1, NM_004448.2, NM_004448.3, NM_001005862.1, NM_001005862.2, NM_001289938.1, NM_001289937.1, NM_001289936.1, BC080193, BC110392, BC156755, BC167147, BM678576, NM_001289936.2, NM_001005862.3, NM_001289938.2, NM_001289937.2, NM_004448.4
UniProt ID P04626
Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Directed Evolution of Scanning Unnatural-Protease-Resistant (SUPR) Peptides for in Vivo Applications
Fiacco, Kelderhouse, Hardy et al
Chembiochem (2016)
Cited by 41
AI Summary: OriGene’s TL320342 lentiviral GFP shRNA kit was used to transfect cells with Her2-targeting or control constructs, enabling functional studies of SUPR peptides in the referenced research.
Snippet: Cells were transfected either with Her2 29 mer shRNA constructs in lentiviral GFP vector or with negative control GFP vector (TL 320342 kit, Origene, Rockville, MD)
Transmembrane Domain Targeting Peptide Antagonizing ErbB2/Neu Inhibits Breast Tumor Growth and Metastasis
Arpel, Sawma, Spenlé et al
Cell Rep (2014) 8 (6), 1714-21 DOI: 10.1016/j.celrep.2014.07.044
Cited by 52
AI Summary: OriGene’s pGFP-C-shLenti 29MER plasmid vectors (TL320342A and TL320342B) were used to generate lentiviruses for gene knockdown experiments in this study investigating peptide antagonists of ErbB2 in breast cancer.
Snippet: Lentiviruses producing HEK293T cells were transfected using the JetPEI transfection reagent (PolyPlus Transfection) with a set of two different pGFP-C-shLenti 29MER plasmid vectors: TL320342A, TL320342B (OriGene) and three lentivirus packaging plasmid vectors ... Cite SaveSaving
Showing 1-2 of 2 papers.
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