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ATM Human shRNA Plasmid Kit (Locus ID 472)

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SKU
TL320267
ATM - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "ATM or NM_000051"

Specifications
Specifications
Product Data
Locus ID 472
Synonyms AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components ATM - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 472). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC007023, NM_000051, NM_138292, NM_138293, NM_001351834, NM_001351835, NM_001351836, NM_138292.1, NM_138292.2, NM_138292.3, NM_000051.3, BC022306, BC022307, BC061584, BC137169, BC152385, BC152389, NM_000051.4
UniProt ID Q13315
Summary The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. provided by RefSeq, Aug 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations
Cheng, Zhao, Tse et al
PNAS (2017)
AI Summary: OriGene products GFP-Atm-shRNA (TL320267) and GFP-Atr-shRNA (TL519184) were used in this study to selectively reduce ATM and ATR protein levels, enabling the investigation of their distinct roles in regulating excitatory and inhibitory synaptic vesicle populations.
Snippet: GFP-Atm-shRNA (TL320267) and GFP-Atr-shRNA (TL519184) were supplied by Origene, mCherry-Atm-shRNA (MSH026597) was obtained from Genecopoeia, GFP-C1-PLCdelta-PH (21179) was provided by Addgene
Showing 1-1 of 1 papers.
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