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MEG3 Human shRNA Plasmid Kit (Locus ID 55384)

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SKU
TL320132
MEG3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 55384
Synonyms FP504; GTL2; LINC00023; NCRNA00023; onco-lncRNA-83; prebp1; PRO0518; PRO2160
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components MEG3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 55384). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NR_002766, NR_003530, NR_003531, NR_033358, NR_033359, NR_033360, NR_046464, NR_046465, NR_046466, NR_046467, NR_046468, NR_046469, NR_046470, NR_046471, NR_046472, NR_046473, BC023543, BC036882, BC051294, BC062783, BC092509
Summary This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. provided by RefSeq, Mar 2012
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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Deregulated expression of the imprinted DLK1-DIO3 region in glioblastoma stemlike cells: tumor suppressor role of lncRNA MEG3
Buccarelli, Lulli, Giuliani et al
Neuro Oncol (2020) 22 (12), 1771-1784 DOI: 10.1093/neuonc/noaa127
Cited by 57
AI Summary: OriGene products, specifically the MEG3 cDNA clone (RC209879) and MEG3 shRNA (TL313155), were used in this study to overexpress and knock down MEG3 in glioblastoma stemlike cells, enabling the authors to investigate the tumor suppressor role of MEG3 in regulating cell growth, migration, and tumorigenicity.
FigureFigureFigure
Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis
Bi, Wang, Li et al
Med Sci Monit (2020) 26, e920793 DOI: 10.12659/MSM.920793
AI Summary: OriGene products, specifically the lncRNA MEG3-plasmid and lncRNA MEG3-shRNA, were used to manipulate MEG3 expression in human pulmonary microvascular endothelial cells, enabling the authors to demonstrate MEG3’s role in regulating apoptosis in a COPD model.
FigureFigureFigure
Mechanism associated with aberrant lncRNA MEG3 expression in gestational diabetes mellitus
Zhang
Exp Ther Med (2019) 18 (5), 3699-3706 DOI: 10.3892/etm.2019.8062
AI Summary: OriGene products, specifically the pGFP-C-shLenti Vector shRNA plasmid (cat. no. TL320132C) and the scrambled shRNA plasmid (cat. no. TR30021), were used in this study to manipulate lncRNA MEG3 expression in HTR-8/SVneo cells, enabling the investigation of MEG3's role in gestational diabetes mellitus.
Snippet: TTG CA-3';pGFP-C-shLenti Vector;cat. no. TL 320132C) and the scrambled shRNA plasmid (sh-control;cat. no. TR30021) were purchased from OriGene. HTR-8/SVneo cells were seeded into 6-well
FigureFigureFigure
Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163
Su, Han, Wu et al
Tumour Biol. (2015)
Cited by 67
AI Summary: OriGene supplied the Meg3 transgene, shMeg3 (short-hairpin interfering RNA for Meg3), control scrambled sequence, miR-3163 mimics, miR-3163 antisense oligonucleotides, and control null sequence, which were used to manipulate gene and microRNA expression to investigate their roles in regulating Skp2 and non-small cell lung cancer cell growth in this study.
Snippet: Meg3 transgene, short-hairpin interfering RNA for Meg3 (shMeg3), control scrambled sequence (scr), miR-3163 mimics (miR-3163), miR-3163 antisense oligonucleotides (as-miR-3163), and control null sequence (null) were obtained from OriGene (Beijing, China). ... Cite SaveSaving
Showing 1-4 of 4 papers.
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