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ISG15 Human shRNA Plasmid Kit (Locus ID 9636)

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SKU
TL319471
ISG15 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "ISG15 or NM_005101"

Specifications
Specifications
Product Data
Locus ID 9636
Synonyms G1P2; hUCRP; IFI15; IMD38; IP17; UCRP
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components ISG15 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 9636). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC009507, NM_005101, NM_005101.1, NM_005101.2, NM_005101.3, BC009507.2, BM712238, NM_005101.4
UniProt ID P05161
Summary The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. provided by RefSeq, Dec 2012
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
Liu, Lee, Parker et al
Nat Microbiol (2021) 6 (4), 467-478 DOI: 10.1038/s41564-021-00884-1
Cited by 343
AI Summary: OriGene’s shRNA lentiviral particles targeting ISG15 (TL319471V), IFIH1 (TL303992V), and scrambled shRNA control lentiviral particles were used in this study to selectively knock down gene expression and investigate the roles of ISG15 and MDA5 (IFIH1) in antiviral innate immune responses.
Snippet: Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15, the mechanistic;Scrambled short hairpin (sh)RNA control lentiviral particles and shRNA lentiviral particles targeting ISG15 (TL319471V) or IFIH1 (TL303992V) were purchased from OriGene
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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