alpha Synuclein (SNCA) Human shRNA Plasmid Kit (Locus ID 6622)

SKU TL318860

SNCA - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 6622
• Synonyms: NACP; PARK1; PARK4; PD1
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: SNCA - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6622). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_000345, NM_001146054, NM_001146055, NM_007308, NM_000345.1, NM_000345.2, NM_000345.3, NM_007308.1, NM_007308.2, NM_001146054.1, NM_001146055.1, BC108275, BC013293, NM_001146054.2, NM_001146055.2, NM_000345.4
• UniProt ID: P37840
• Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient