BCL2 Human shRNA Plasmid Kit (Locus ID 596)
SKU
TL316461
BCL2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 596 |
|---|---|
| Synonyms | Bcl-2; PPP1R50 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | BCL2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 596). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC027258, NM_000633, NM_000657, NM_000633.1, NM_000633.2, NM_000657.1, NM_000657.2, BC027258.1, NM_000657.3, NM_000633.3 |
| UniProt ID | P10415 |
| Summary | This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells
Son, Pratheeshkumar, Divya et al
J. Biol. Chem. (2017)
Son, Pratheeshkumar, Divya et al
J. Biol. Chem. (2017)
AI Summary: In this study, OriGene’s Nrf2 shRNA lentiviral particles and Bcl-2 shRNA lentiviral particles were used to genetically knock down Nrf2 and Bcl-2, respectively, demonstrating their roles in regulating apoptosis and autophagy in nickel-transformed cells.
Snippet: Page 1. Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells Young-Ok Son a,b,c,d,*, Poyil Pratheeshkumar a,b,d, Sasidharan Padmaja Divyab, Zhuo Zhang b, Xianglin Shi ... All 2 versions Cite SaveSaving
Inhibition of Bcl-2 potentiates AZD-2014-induced anti-head and neck squamous cell carcinoma cell activity
Li, Cui
Biochem. Biophys. Res. Commun. (2016)
Li, Cui
Biochem. Biophys. Res. Commun. (2016)
Cited by 12
AI Summary: OriGene contributed Bcl-2 shRNA lentiviruses (Bcl-2-shRNA-a and Bcl-2-shRNA-b) used to knock down Bcl-2 expression in SQ20B cells, enabling the study of Bcl-2’s role in resistance to AZD-2014 in head and neck squamous cell carcinoma.
Snippet: Each non-overlapping Bcl-2-shRNA (“-a/-b”, both were designed by ORIGENE, Shanghai, China) lentivirus (10 μl/ml) was added to SQ20B cells for 24 h. Afterwards, cells were cultured in fresh medium, and were subjected to puromycin (2.5 μg/ml, Sigma) selection ... Cite SaveSaving
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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