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MUM1 (IRF4) Human shRNA Plasmid Kit (Locus ID 3662)

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SKU
TL315501
IRF4 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "MUM1 or NM_001195286"

Specifications
Specifications
Product Data
Locus ID 3662
Synonyms LSIRF; MUM1; NF-EM5; SHEP8
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components IRF4 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3662). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC015752, NM_001195286, NM_002460, NR_036585, NR_046000, NM_002460.1, NM_002460.2, NM_002460.3, NM_001195286.1, BC015752.1, BM551611, NM_001195286.2, NM_002460.4
UniProt ID Q15306
Summary The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Aug 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions
Bastea, Liou, Pandey et al
Cancer Res (2019) 79 (7), 1535-1548 DOI: 10.1158/0008-5472.CAN-18-1153
AI Summary: In this study, OriGene products—including IRF4 (NM_002460) qPCR primers and IRF4 (TA500648) antibody—were used to assess the expression and regulation of interferon regulatory factor 4, helping to elucidate how pomalidomide modulates macrophage polarization in pancreatic lesions.
FigureFigure
Showing 1-1 of 1 papers.
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