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ADFP (PLIN2) Human shRNA Plasmid Kit (Locus ID 123)

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SKU
TL314932
PLIN2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "ADFP or NM_001122"

Specifications
Specifications
Product Data
Locus ID 123
Synonyms ADFP; ADRP
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components PLIN2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 123). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001122, NR_038064, NM_001122.1, NM_001122.2, NM_001122.3, BC005127, BC005127.2, NM_001122.4
UniProt ID Q99541
Summary The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Mar 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Ippolito, Comito, Parri et al
Cancer Res (2022) 82 (7), canres.0914.2021 DOI: 10.1158/0008-5472.CAN-21-0914
AI Summary: OriGene’s PLIN2 lentiviral particles (PLIN2 #TL314932V) were used to generate PLIN2 knockdown prostate cancer cells, enabling the study of how lactate-driven lipid metabolism and epigenetic changes contribute to cancer progression.
Snippet: … In prostate cancer (PCa), cancer-associated fibroblasts are major contributors of secreted lactate, which Save;RNAiMAX transfection reagent (#13778150;Thermo Fisher), 129 according to manufacturer’s instructions. shPLIN2 cells were obtained by infecting 130 with lentiviral particles (PLIN2 #TL314932V, OriGene Technologies Inc., Rockville, 131 MD, USA) for 24-48h. …
Showing 1-1 of 1 papers.
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