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DNMT1 Human shRNA Plasmid Kit (Locus ID 1786)

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SKU
TL313404
DNMT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "DNMT1 or NM_001130823"

Specifications
Specifications
Product Data
Locus ID 1786
Synonyms ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components DNMT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 1786). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001130823, NM_001318730, NM_001318731, NM_001379, NM_001379.1, NM_001379.2, NM_001379.3, NM_001130823.1, NM_001130823.2, BC092517, BC126227, BC144093, NM_001130823.3
UniProt ID P26358
Summary This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma
Li, Wang, Wu et al
Cancer Res. (2018)
AI Summary: OriGene products, including lentiviral shRNAs for DNMT1, DNMT3a, CXCR4 (#TL514641, #TL313404, #TL500549, #TL304938, #TL500383, #TL313630) and a CXCR4 overexpression construct (#RC202069), were used to manipulate gene expression and investigate the roles of these genes in CXCL12 regulation and tumor progression in osteosarcoma.
Snippet: Knockdown of homo or 126 mouse DNMT1, DNMT3a, CXCR4, and overexpression of CXCR4 was achieved using lentiviral 127 shRNAs (#TL514641, #TL313404, #TL500549, #TL304938, #TL500383, #TL313630, and #RC202069, 128 OriGene)
Cancer associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation
Xiao, Zhou, Rucki et al
Cancer Res. (2016)
AI Summary: OriGene’s DNMT1 shRNA lentiviral particles were used for RNA interference experiments to investigate the role of DNMT1-mediated DNA methylation in reprogramming cancer-associated fibroblasts in pancreatic cancer.
Snippet: RNA interference shRNA experiments were performed with the lentivirus encoding validated short hairpin RNA directed against SOCS1(Thermo Scientific), DNMT1(OriGene Technologies, Rockville, MD, USA) or corresponding controls, as previously described(19). ... Cite SaveSaving
Showing 1-2 of 2 papers.
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