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EDEM1 Human shRNA Plasmid Kit (Locus ID 9695)

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SKU
TL313302
EDEM1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 9695
Synonyms EDEM
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components EDEM1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 9695). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_014674, NM_014674.1, NM_014674.2, BC019088, BC019088.1
UniProt ID Q92611
Summary Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation
Frabutt, Wang, Riaz et al
J. Virol. (2017)
AI Summary: OriGene products, including the pGFP-C-shLenti vector, EDEM2 shRNA (TL304849), and a scrambled control (TR30021), were used to generate lentiviral particles for gene silencing experiments that helped elucidate the role of EDEM2 in the ER-associated degradation of influenza A virus hemagglutinin.
Snippet: 360 Lentiviral particles were produced through co-transfection of the Origene pGFP-C-shLenti 361 Page 19. 19 EDEM2 (TL304849), and a scrambled control (TR30021) were purchased from OriGene. 387 Real-time qPCR analysis;... 360 Lentiviral particles were produced through co-transfection of the Origene pGFP-C-shLenti 361 Page 19. 19 ... EDEM2 (TL304849), and a scrambled control (TR30021) were purchased from OriGene. 387 Real-time qPCR analysis. ...;... 360 Lentiviral particles were produced through co-transfection of the Origene pGFP-C-shLenti 361 Page 19. 19 ... EDEM2 (TL304849), and a scrambled control (TR30021) were purchased from OriGene. 387 Real-time qPCR analysis.
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