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GAB2 Human shRNA Plasmid Kit (Locus ID 9846)

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SKU
TL312875
GAB2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "GAB2 or NM_012296"

Specifications
Specifications
Product Data
Locus ID 9846
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components GAB2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 9846). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_012296, NM_080491, NM_012296.1, NM_012296.2, NM_012296.3, NM_080491.1, NM_080491.2, BC131711, BC152459, NM_080491.3
UniProt ID Q9UQC2
Summary This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. provided by RefSeq, Nov 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Gab2 Ablation Reverses the Stemness of HER2-Overexpressing Breast Cancer Cells
Zhang, Chen, Gong et al
Cell. Physiol. Biochem. (2018) 50 (1), 52-65 DOI: 10.1159/000493957
AI Summary: OriGene contributed to this study by providing the lentiviral-based pLKO.1 Gab2 short hairpin RNA (shRNA), which was used to knock down Gab2 expression in HER2-overexpressing breast cancer cells.
Snippet: confirmed by sequencing. T47D-HER2-shGab2 cells were stably transfected with pLKO.1 Gab2 short hairpin RNA (shRNA). Lentiviral-based pLKO.1 Gab2 shRNA was purchased from Origene (Rockville, MD). Stable colonies were
Showing 1-1 of 1 papers.
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