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SynCAM (CADM1) Human shRNA Plasmid Kit (Locus ID 23705)

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SKU
TL312210
CADM1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 23705
Synonyms BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175; sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components CADM1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 23705). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001098517, NM_001301043, NM_001301044, NM_001301045, NM_014333, NM_014333.1, NM_014333.2, NM_014333.3, NM_001098517.1, NM_001301045.1, NM_001301044.1, NM_001301043.1, BC035930, BC047021, BC125102, BC125103, BM309987, NM_014333.4, NM_001301044.2, NM_001098517.2, NM_001301043.2, NM_001301045.2
UniProt ID Q9BY67
Summary Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1
Zhang, Zhong, Luo et al
Onco Targets Ther (2019) 12, 7993-8002 DOI: 10.2147/OTT.S206180
AI Summary: OriGene products, including the CADM1 shRNA (TL312210) and CADM1 overexpression vector (SC115048), were used in this study to experimentally decrease and increase CADM1 expression, respectively, enabling the authors to investigate the role of CADM1 in breast cancer progression.
Snippet: SR308445, OriGene, Beijing, China) and short hairpin RNA (shRNA) (sh-CADM1;No. TL312210, OriGene) targeting human CADM1 gene were used to down-regulate CADM1 expression SC115048, OriGene) was used to up-regulate CADM1 expression
FigureFigureFigure
Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-κB Inhibitor A20 and Constitutive NF-κB Signaling
Pujari, Hunte, Thomas et al
PLoS Pathog. (2015) 11 (3), e1004721 DOI: 10.1371/journal.ppat.1004721
Cited by 56
AI Summary: OriGene Technologies' packaging plasmids were used to produce lentiviral particles for shRNA-mediated knockdown of CADM1, enabling the authors to investigate CADM1's role in HTLV-1 Tax-mediated NF-κB activation.
Snippet: Lentiviral particle production and targeT-cell infection To investigate the role of CADM1 in Tax-mediated NF-κB activation, a CADM1-specific shRNA construct was used to knockdown CADM1 expression. HEK 293-T-cells in 6-well culture plates were transfected with 1 μg of control scrambled shRNA or CADM1 shRNA with 2 μg of packaging plasmids (OriGene Technologies) containing puromycin selection marker using FuGENE 6 (Roche). …
FigureFigureFigure
Showing 1-2 of 2 papers.
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