IL6R Human shRNA Plasmid Kit (Locus ID 3570)
SKU
TL312161
IL6R - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
4 Weeks*
Specifications
| Product Data | |
| Locus ID | 3570 |
|---|---|
| Synonyms | CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | IL6R - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3570). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_000565, NM_001206866, NM_181359, NM_181359.1, NM_181359.2, NM_000565.1, NM_000565.2, NM_000565.3, NM_001206866.1, BC089410, BC035327, BC132684, BC132686, BM911928, NM_181359.3, NM_001206866.2, NM_000565.4 |
| UniProt ID | P08887 |
| Summary | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. provided by RefSeq, Aug 2020 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer
Tsoi, Man, Chau et al
Cancers (Basel) (2021) 13 (7) DOI: 10.3390/cancers13071511
Tsoi, Man, Chau et al
Cancers (Basel) (2021) 13 (7) DOI: 10.3390/cancers13071511
Cited by 49
AI Summary: In this study, OriGene’s IL6R shRNA (Cat# TL312482) was used to knock down IL-6R expression, enabling the authors to demonstrate that reducing IL-6R levels could compromise BQ-mediated tamoxifen resistance in breast cancer cells.
Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells
Mishra, Dingli
Leukemia (2019)
Mishra, Dingli
Leukemia (2019)
AI Summary: OriGene’s pGFP-C-shLenti vectors (shRNA targeting IL-6R and scramble control) were used to knock down IL-6R expression in multiple myeloma cells, enabling the study of metformin’s effects on IL-6 signaling.
Snippet: IL6R knock-down (KD). pGFP-C-shLenti vectors (4 shRNA targeting IL-6R and 1 scramble control) were purchased from Origene. Lentiviral vector particles were generated in HEK293T cells using pMD2.G (Addgene) and psPAX2 (Addgene)
Showing 1-2 of 2 papers.
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in shipping.
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