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MDMX (MDM4) Human shRNA Plasmid Kit (Locus ID 4194)

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SKU
TL311528
MDM4 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 4194
Synonyms BMFS6; HDMX; MDMX; MRP1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components MDM4 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4194). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001204171, NM_001204172, NM_001278516, NM_001278517, NM_001278518, NM_001278519, NM_002393, NR_024171, NM_002393.1, NM_002393.2, NM_002393.3, NM_002393.4, NM_001204172.1, NM_001204171.1, NM_001278518.1, NM_001278516.1, NM_001278519.1, NM_001278517.1, BC067299, BC067299.1, BC025993, BC105106, BC143431, BC143432, BM475824, NM_002393.5
UniProt ID O15151
Summary This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. provided by RefSeq, Feb 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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