MMP7 Human shRNA Plasmid Kit (Locus ID 4316)
SKU
TL311438
MMP7 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 4316 |
|---|---|
| Synonyms | MMP-7; MPSL1; PUMP-1 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | MMP7 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4316). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC003635, NM_002423, NM_002423.2, NM_002423.3, NM_002423.4, BC003635.2, NM_002423.5 |
| UniProt ID | P09237 |
| Summary | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. provided by RefSeq, Jan 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop
Zeng, Yao, Chen et al
Oncotarget (2016)
Zeng, Yao, Chen et al
Oncotarget (2016)
Cited by 110
AI Summary: OriGene products, specifically shRNA plasmids targeting HPSE (TL307138), MMP-7 (TL311438), syndecan-1 (TL309598), and a scrambled control (TR30021), were used in this study to selectively silence gene expression and investigate the roles of these genes in S1P-induced epithelial-mesenchymal transition in hepatocellular carcinoma.
Showing 1-1 of 1 papers.
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