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COX2 (PTGS2) Human shRNA Plasmid Kit (Locus ID 5743)

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SKU
TL310074
PTGS2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 5743
Synonyms COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components PTGS2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 5743). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_000963, NM_000963.1, NM_000963.2, NM_000963.3, BC013734, BC013734.1, BM978796, NM_000963.4
UniProt ID P35354
Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. provided by RefSeq, Feb 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-κB pathway
Li, Xie, Xu et al
Reproductive Biology (2022) 22 (4), 100696 DOI: 10.1016/j.repbio.2022.100696
Cited by 38
AI Summary: OriGene contributed the PGFP-C-shLenti shRNA Vector (TR30023) and COX2 (PTGS2) human shRNA lentiviral particle (TL310074V), which were used to silence PTGS2 expression and investigate its role in LPS-induced inflammatory responses and trophoblast invasion in preeclampsia.
Snippet: PGFP-C-shLenti shRNA Vector (TR30023) and COX2 (PTGS2) human shRNA lentiviral particle (TL310074V) were purchased from Origene (Rockville, MD, USA). Polyethylenimine (linear) (MTP2500;MesGen Biotech, Piscataway, NJ) was applied to transfect lentiviral plasmids into HEK293 cells (CL-0001;Procell Life
Showing 1-1 of 1 papers.
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