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RRM2 Human shRNA Plasmid Kit (Locus ID 6241)

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SKU
TL309700
RRM2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 6241
Synonyms C2orf48; R2; RR2; RR2M
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components RRM2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6241). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001034, NM_001165931, NM_001034.1, NM_001034.2, NM_001034.3, NM_001165931.1, BC030154, BC030154.1, BC001886, BC028932, BM994533, NM_001034.4
UniProt ID P31350
Summary This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. provided by RefSeq, Sep 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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IGF2BP3 regulates the expression of RRM2 and promotes the progression of rheumatoid arthritis via RRM2/Akt/MMP-9 pathway
Ban, Li, Xing et al
PLoS One (2024) 19 (5), e0303593 DOI: 10.1371/journal.pone.0303593
Cited by 10
AI Summary: OriGene’s RRM2 human shRNA lentiviral particles (Cat.No: TL309700V) and control lentiviral particles (Cat.No.: TR30021V) were used to knock down RRM2 expression in MH7A cells, enabling the authors to investigate the role of RRM2 in rheumatoid arthritis progression.
Snippet: TR30021V) were purchased from Origene. …sc-108080) were purchased from Santa Cruze. RRM2 human shRNA lentiviral particles (Locus ID 6241, Cat.No: TL309700V) and control lentiviral particles (Cat.No.: TR30021V) were purchased from Origene. …
FigureFigureFigure
Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer
Hsieh, Ling, Setiawan et al
Chem Biol Interact (2024) 395, 111004 DOI: 10.1016/j.cbi.2024.111004
Cited by 41
AI Summary: OriGene products, specifically the TXNRD1 shRNA (OriGene Cat#: TL309700V) and Scr shRNA control (OriGene Cat#: TR30021V), were used to stably knock down TXNRD1 gene expression in order to investigate its role in ferroptosis and immunotherapy resistance in head and neck cancer cells.
Snippet: t#: TL309700V) were obtained from Origene (Rockville, MD, USA) to stably knock down the corresponding gene expression following the manufacturer's protocol (Supplementary Figure S1). The nontarget sequence (Scr shRNA, Origene Cat#: TR30021V) was used as control. Transfection was performed for
RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer
Yang, Lin, Guo et al
Cancer Cell Int (2020) 20 (1), 587 DOI: 10.1186/s12935-020-01689-8
Cited by 159
AI Summary: In this study, OriGene products including the RRM2 Human cDNA ORF Clone (Cat# RC201057) and Human RRM2 siRNA (Cat# SR307128) were used to manipulate RRM2 expression in liver cancer cells, enabling the authors to investigate RRM2’s role in protecting against ferroptosis and its potential as a diagnostic biomarker for liver cancer.
Snippet: of biomarkers in addition to classic alpha fetoprotein (AFP) definitely increases diagnostic accuracy and sensitivity [25–27]. Given that suppressing ferroptosis is closely correlated with liver tumorigenesis, serum biomarkers that reflect ferroptosis inhibition may have potential diagnostic efficiency. However, the discovery and verification of such liver cancer biomarkers are still lacking. R
FigureFigureFigure
Showing 1-3 of 3 papers.
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