RUNX2 Human shRNA Plasmid Kit (Locus ID 860)
SKU
TL309683
RUNX2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 860 |
|---|---|
| Synonyms | AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | RUNX2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 860). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001015051, NM_001024630, NM_001278478, NM_004348, NR_103532, NR_103533, NM_001024630.1, NM_001024630.2, NM_001024630.3, NM_001015051.1, NM_001015051.2, NM_001015051.3, NM_004348.1, NM_004348.2, NM_004348.3, NM_001278478.1, BC108919, BC108920, BC160022, NM_001369405, NM_001278478.2 |
| UniProt ID | Q13950 |
| Summary | This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. provided by RefSeq, Jul 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age
Fang, Cao, Zhu et al
Cell Rep (2021) 37 (6), 109981 DOI: 10.1016/j.celrep.2021.109981
Fang, Cao, Zhu et al
Cell Rep (2021) 37 (6), 109981 DOI: 10.1016/j.celrep.2021.109981
Cited by 48
AI Summary: In this study, OriGene’s RUNX2/GFP lentivector (Cat#: RC212884L4) and human shRNA plasmids targeting RUNX3 (Cat#: TL309682) and RUNX2 (Cat#: TL309683) were used to manipulate the expression of these transcription factors in human T cells, enabling investigation of their roles in regulating CD73 expression and memory T cell function.
Snippet: oned into a commercial lentivector containing a GFP reporter gene (pCDH-GFP-Em-CD513B-1 from System Biosciences). To overexpress RUNX2 in human T cells, we purchased commercial RUNX2/GFP lentivector (Origene, Cat#: RC212884L4). To knockdown RUNX3 or RUNX2 in human T cells, we used RUNX3 or RUNX2 human shRNA plasmid containing GFP reporter gene (Origene, Cat#: TL309682 for RUNX3;Cat#: TL309683 for
Showing 1-1 of 1 papers.
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