SHMT2 Human shRNA Plasmid Kit (Locus ID 6472)
SKU
TL309453
SHMT2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 6472 |
|---|---|
| Synonyms | GLYA; HEL-S-51e; NEDCASB; SHMT |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | SHMT2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6472). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC032584, NM_001166356, NM_001166357, NM_001166358, NM_001166359, NM_005412, NR_029415, NR_029416, NR_029417, NR_048562, NM_005412.1, NM_005412.2, NM_005412.3, NM_005412.4, NM_005412.5, NM_001166359.1, NM_001166357.1, NM_001166358.1, NM_001166356.1, BC032584.1, BC011911, BC011911.2, BC008066, BC008711, BC013677, BC025355, BC044211, BC091501, NM_001166356.2, NM_005412.6 |
| UniProt ID | P34897 |
| Summary | This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2009 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
SHMT2 Induces Stemness and Progression of Head and Neck Cancer
Jin, Jung, Lim et al
Int J Mol Sci (2022) 23 (17) DOI: 10.3390/ijms23179714
Jin, Jung, Lim et al
Int J Mol Sci (2022) 23 (17) DOI: 10.3390/ijms23179714
Cited by 18
AI Summary: OriGene’s pGFP-C-shLenti vector (catalog No: TL309453V) was used to silence SHMT2 expression in head and neck cancer cell lines, enabling the study of SHMT2’s role in cancer progression and stemness.
Snippet: detection (Bio-Rad Laboratories, Inc., Hercules, CA, USA). 4.6. Short-Hairpin RNA (shRNA) Transfection SHMT2 expression was silenced using a commercial pGFP-C-shLenti vector (catalog No: TL309453V, OriGene Technologies, Inc., Rockville, MD, USA). This vector was designed to specifically inhibit SHMT2 expression (shSHMT2-1:5′-AAG ACTGCCAAGCTCCAGGATTTCAAATC-3′;shSHMT2-2:5′- AAGTCAAAGCACACCT
Showing 1-1 of 1 papers.
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