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SLC7A5 Human shRNA Plasmid Kit (Locus ID 8140)

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SKU
TL309279
SLC7A5 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 8140
Synonyms 4F2LC; CD98; D16S469E; E16; LAT1; MPE16
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components SLC7A5 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 8140). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_003486, NM_003486.1, NM_003486.2, NM_003486.3, NM_003486.4, NM_003486.5, NM_003486.6, BC039692, BC039692.2, BC014177, BC042600, BC114608
UniProt ID Q01650
Summary The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Aptamer-guided delivery of miR-126 suppresses glioblastoma stem-like cell invasion and tumor progression
Castellani, Buccarelli, Affinito et al
Molecular Therapy Nucleic Acids (2026) 37 (4), 103103 DOI: 10.1016/j.omtn.2026.103103
AI Summary: OriGene products—specifically the shLAT1-GFP (TL309279), shPLXNB2-GFP (TL317033), and shSPRED1-GFP (TL301404) lentiviral vectors—were used for gene silencing experiments to investigate the roles of LAT1, PLXNB2, and SPRED1 in glioblastoma stem-like cell invasion and tumor progression.
Snippet: For LAT1, PLXNB2, and SPRED1 silencing, short hairpin shLAT1-GFP (TL309279), shPLXNB2-GFP (TL317033), and shSPRED1-GFP (TL301404) lentiviral vectors were purchased from OriGene Technologies (Rockville, MD, USA)
Showing 1-1 of 1 papers.
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